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Th1L06 Microtubules
Description
Medicine Y1 (Theme 1 | Cells and organelles) Mind Map on Th1L06 Microtubules, created by Emma Allde on 16/08/2016.
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medicine y1
theme 1 | cells and organelles
Mind Map by
Emma Allde
, updated more than 1 year ago
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Emma Allde
almost 8 years ago
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Emma Allde
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Resource summary
Th1L06 Microtubules
structure
composed of micro-tubule-associated proteins (MAPs)
Tubulin is the monomer of microtubules
consists of one molecule or alpha and beta-tubulin
Alpha tubulin, positive end
Beta-tubulin, negative end
Assembly and disassembly of the microtubule
similar to the assembly of actin filaments
GTP bound monomers (alpha-tubulin) assemble onto microtubule
GDP bound beta-tubulin monomers dissociate rapidly
long, relatively stiff hollow tubes
thirteen columns of tubulin polymer
approximately 25nm
can be rapidly disassembled and reassembled
polar and highly dynamic
visible using EM or light microscopy
Functions
polymerised in centrosomes
minus end remains close the centrosome and the plus end points outward towards the cell periphery
Stabilise the shape of platelets and axons
protrusions are activated by cuts and formed by microfilaments allowing them to adhere to one another and form a clot
Anchoring
organise the ER of a cell
Cell motility
Cilia and flagella
E.g. in respiratory epithelium
Shows 9:2 structure
Microtubules slide along one another causing the cilium to bend via processive motor proteins
Dyenin
minus-ended microtubule associated motor protein near nucleus
Kinesin
moves towards (+) ends (cell periphery)
Stays attached to the microtubule throughout the ATP hydrolysis cycle (unlike mysosin)
Involved in separation of chromosomes during cell division
Colchicine, vinblastine and taxol
anti-cancer therapeutics
inhibit the function of the mitotic spindle and thus cell division
Colchicine and vinblastine destabilise microtubules
Taxol stabilises microtubules
inhibits microtubule polymerization by binding to tubulin
involved in the movement of organelles, e.g. synaptic vesicles along axons to synapses
Composed of heavy chain (binds to microtubule) and light chain (binds to what needs to be moved)
Vesicles move about 10cm/day which take more than a week down an entire axon
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